Design and Evaluation of Self-nanoemulsified Drug Delivery System (snedds) of Docetaxel by Optimizing the Particle Size Using Response Surface Methodology

The aim of the current study was to design an self-nanoemulsified drug delivery system (SNEDDS) of docetaxel by optimizing the particle size using response surface methodology. SNEDDS were prepared using surfactant, co-surfactant and oils/co-solvents. A IV optimal design for 3 factors at 3-level each was employed systematically optimize particle size. The particle size was taken as dependent variable. Cremophore-EL, polysorbate-80 and ethanol were taken as independent variables. The counter plot and 3D plot were drawn and optimum formulation was selected by feasibility and grid searches. The polynomial mathematical model generated for response were found to be Y = +53.66 +22.01 * A +41.76 * B -1.31 * C +17.79 * A * B +1.06 * A * C -2.76 * B * C and that found to be significant (P < 0.05). Validation of optimization study performed using confirmatory runs, indicated very high degree of prognostic ability of response surface methodology with mean percent error (± S.D.) 5.11.